The cytoplasmic nucleoproteins of azo dye-induced rat liver tumors.
نویسندگان
چکیده
منابع مشابه
Antigenic changes in nonhistone proteins during azo dye hepatocarcinogenesis.
We have investigated the appearance of specific nonhistone proteins during azo dye-induced hepatocarcinogenesis in the rat. Groups of animals fed azo dye-containing diet were sacrificed at approximately 3-week intervals, portions of their livers were examined histologically, and the remaining material was fractionated into chromatin and cytoplasmic fractions. Livers of the azo dye-fed animals e...
متن کاملDiet and Azo Dye Tumors: a Period When the Dye is Not Fed*
Although it is @ve11 recognized that rats fed azo dyes develop tumors at rates that depend upon the diet fed with the dye (@28), the mechanism by which this is accomplished is unknown. One possi bility is that pertinent diets alter the metabolism of the dye and thus alter the concentration of ef fective carcinogen; another, that diet can effect changes in normal cellular constituents that eithe...
متن کاملA transplantable rat liver tumor induced by 4-dimethylaminoazobenzene.
Armstrong, Gray, and Ham (1) showed that growth of azo dye-induced liver tumors on the yolk sacs of chicken embryos was more likely if metastasizing tumors were used. By injecting such metastasizing tumors, we were able in 1951 to es tablish a tumor induced by 4-dimethylaminoazobenzene in transplantable form. Since then the tumor has become widely used in cancer research laboratories in this co...
متن کاملDye Carcinogenesis*
With the use of 2.1 M sucrose solution, nuclei were isolated from normal, control, and azo preneoplastic livers, and from azo dye-inducedliver tumors of rats. Four consecu tive extractions of nuclear sap in isotonic saline-phosphate buffer solubiized 49 and 37 per cent of the nitrogen of liver and tumor nuclei, respectively. Velocity sedimentation analyses revealed that the soluble nuclear macr...
متن کاملEffect of antioxidant vitamins A, C, E and their analogues on azo-dye binding protein in liver of rats treated with p-dimethylaminoazobenzene.
p-Dimethylaminoazobenzene (DAB) is an azo-dye and known to cause liver tumour in rats. Azo-dye binding protein is a specific cytosolic protein involved in the translocation of azo-dye carcinogen metabolites from liver cytoplasm into the nucleus. Administration of vitamin A (40,000 and 50,000 IU), L-ascorbic acid (500 and 1000 mg) and vitamin E succinate (200-500 mg) reduced the amount of azo-dy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 16 7 شماره
صفحات -
تاریخ انتشار 1956